O-002 Human genes: A journey through prehistory

Chorea: A Journey through History

The original descriptions of chorea date from the Middle Ages, when an epidemic of "dancing mania" swept throughout Europe. The condition was initially considered a curse sent by a saint, but was named "Saint Vitus's dance" because afflicted individuals were cured if they touched churches storing Saint Vitus's relics. Paracelsus coined the term chorea Sancti Viti and recognized different forms ...

A journey through disability: a sibling's perspective.

Reviews Chorea: A Journey through History

The original descriptions of chorea date from the Middle Ages, when an epidemic of ‘‘dancing mania’’ swept throughout Europe. The condition was initially considered a curse sent by a saint, but was named ‘‘Saint Vitus’s dance’’ because afflicted individuals were cured if they touched churches storing Saint Vitus’s relics. Paracelsus coined the term chorea Sancti Viti and recognized different fo...

A Replisome’s journey through the bacterial chromosome

Genome duplication requires the coordinated activity of a multi-component machine, the replisome. In contrast to the background of metabolic diversity across the bacterial domain, the composition and architecture of the bacterial replisome seem to have suffered few changes during evolution. This immutability underlines the replisome's efficiency in copying the genome. It also highlights the suc...

Microsporidia: a journey through radical taxonomical revisions

Microsporidia are obligate intracellular parasites of medical and commercial importance, characterized by a severe reduction, or even absence, of cellular components typical of eukaryotes such as mitochondria, Golgi apparatus and flagella. This simplistic cellular organization has made it difficult to infer the evolutionary relationship of Microsporidia to other eukaryotes, because they lack ma...